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San Francisco 49ers vs. Buffalo Bills: Preview, Predictions and Picks for December 1, 2024

Updated on:
Dec 1, 2024 9:58 PM
The Buffalo Bills, riding a 5-0 home record and 9-2 overall mark, look to build on their impressive start as they return from their bye week to host the San Francisco 49ers at Highmark Stadium on Sunday, December 1, 2024, at 8:20 PM. The 49ers, meanwhile, aim to bounce back from a two-game skid, bringing a 5-6 overall record and 2-3 road mark into the matchup. This clash pits one of the NFL's top teams against a struggling opponent seeking to regain its footing.
San Francisco 49ers vs Buffalo Bills

Current Odds

SF
BUF
Over
48.5
+105
Under
47.5
+133
SF
+25.0
+160
BUF
-25.5
+225
SF
ML
+8000
BUF
ML
-10000

49ers vs Bills statistics

Stat 49ers Bills
Points Per Game 23.6 29.1
Total Yards 394.0 350.8
Yards Passing 255.6 231.6
Yards Rushing 138.4 119.2
Points Allowed Per Game 23.6 19.5
Yards Allowed 316.6 345.9
Pass Yards Allowed 205.8 226.8
Rush Yards Allowed 110.8 119.1

Buffalo Bills recent games

Game Date Opponent Result Score
11/17/24 vs Kansas City Chiefs W 30-21
11/10/24 @ Indianapolis Colts W 30-20
11/3/24 vs Miami Dolphins W 30-27
10/27/24 @ Seattle Seahawks W 31-10
10/20/24 vs Tennessee Titans W 34-10

San Francisco 49ers recent games

Game Date Opponent Result Score
11/24/24 @ Green Bay Packers L 38-10
11/17/24 vs Seattle Seahawks L 20-17
11/10/24 @ Tampa Bay Buccaneers W 23-20
10/27/24 vs Dallas Cowboys W 30-24
10/20/24 vs Kansas City Chiefs L 28-18

Buffalo Bills injuries

  • DeWayne Carter (DT): Injured Reserve
  • Matt Milano (LB): Questionable
  • Tylan Grable (OT): Injured Reserve
  • Keon Coleman (WR): Questionable
  • Dalton Kincaid (TE): Out

San Francisco 49ers injuries

  • Brock Purdy (QB): Questionable
  • Kevin Givens (DT): Questionable
  • Aaron Banks (G): Out
  • Trent Williams (OT): Out
  • Demetrius Flannigan-Fowles (LB): Questionable

49ers vs Bills game info

Type Info
Venue Highmark Stadium
Location Orchard Park, NY
Kickoff Sun 8:20 PM
TV NBC
Temperature 30°
Chance of Rain 51%

49ers vs Bills predictions

The San Francisco 49ers have a tough challenge ahead as they face a formidable Buffalo Bills squad. Keeping an eye on Christian McCaffrey, he appears set to be the workhorse for the 49ers' offense, likely accumulating around 75 rushing yards and possibly adding over 25 receiving yards. His dual-threat capability always makes him a player to watch. Quarterback Brock Purdy may find himself needing to step up his game, potentially throwing for approximately 230 yards and possibly a touchdown or two if he can harness consistency throughout the game. Wide receiver Jauan Jennings could be a key target in the passing game, with expectations of him pulling in around 4 to 5 receptions for over 50 yards.

Turning to the Buffalo Bills, their high-octane offense is primed to impress once again. Josh Allen, pivotal to the Bills' success, looks to have a significant impact with an anticipated 250 passing yards and a couple of touchdowns. His synergy with receiver Amari Cooper could be crucial, with Cooper possibly racking up around 60 receiving yards. The ground game might see a decent share of action with James Cook, who could contribute significantly with over 60 rushing yards, proving vital as the Bills try to balance their offensive attack.

Considering the dynamics and key player performances, the Buffalo Bills are the favorites to clinch this game. Their overall consistency and firepower, especially playing at home where they've been dominant, gives them the edge over the 49ers, who have shown fluctuating form. Buffalo's robust offense, combined with a solid performance from their defense, should see them through as they aim to capitalize on their winning momentum. The stage is set for an exciting matchup, but expect the Bills to have that extra push to secure a victory at Highmark Stadium.

Buffalo Bills

San Francisco 49ers

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